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Prefillable sterile COC syringes for deep cold medications

The SCHOTT TOPPAC® freeze prefillable polymer syringe is ideal for the safe storage and administering of deep-cold medicine. Made of high-quality, inert COC material, the SCHOTT TOPPAC® freeze plastic syringes come with an extensive data package for the entire syringe performance for the intended use in low temperatures. An improved quality control and specifications for critical quality attributes further support assuring that this drug containment and delivery solution is suitable for filling, transporting and storing your drug properly, no matter if it is frozen or thawed


  • Made of high-quality COC material
  • Proven CCI at -100°C for the entire syringe system
  • Complete data package on syringe functionality for intended use
  • Cross-linked silicone for lower extractable silicone quantities and sub-visible particles
  • Improved quality control and specifications for critical to quality attributes
  • Fully automated, state-of-the-art production process
Chemical Resistance
  • The advanced Cyclic Olefin Copolymer (COC) material used in SCHOTT TOPPAC® syringes is inert and stable for a broad range of solutions

  • COC material exhibits excellent barrier properties for water vapor and oxygen permeability, leading to longer drug shelf life

  • No ion or metal release

  • Low protein adsorption and no pH shift

  • COC material manufactured in accordance with EP, JP, and USP class VI (DMF 12132) standards

  • Supported by application specific drug stability studies (e.g. LNP study or protein stability study).

Dimensions & Cosmetics
  • 1ml filling volume

  • Injection moulding of the syringe barrel allows for small tolerances and very little dead space

  • Low extractable silicone quanitites and sub-visible particles

  • Ready-to-use format with tub and nest allows for easy processing

Possible Applications
  • mRNA applications

  • Drugs based on viral vectors

  • Cell and gene therapies

  • Inert COC material with low ions and now heavy metals and extremely low sub-visible particles leads to great drug stability

  • Additional LNP and protein studies confirm stability

  • An extensive data package on syringe performance during and after storing at low temperatures show no loss of CCI

  • Well known RTU packaging configuration allows for fast and easy drug filling process

  • SCHOTT Pharma is a most trusted partner with track record in low temperature applications


SCHOTT Pharma Online Shop.

Our Online Shop provides an easy and fast access to small volume and high quality pharmaceutical packaging solutions. With standardized and pre-tested products we ensure fast delivery times. Our customer care helps you in case you need a product recommendation to safely package your drug.

Open at all times. Quality at all times.

Want to know more? Let's talk.

Whether you need more information, samples, a quote, or advice for a project, we would be delighted to talk to you.

Want to know more? Let's talk.

Whether you need more information, samples, a quote, or advice for a project, we would be delighted to talk to you.